Monte Carlo simulation based on a population PK model showed that a dose regimen of 20 mg/kg 8 hourly achieved 60%T>MIC for P. aeruginosa in 95% of pre-term and 91% of full term neonates. [email protected] This study compared the cost-effectiveness of meropenem with that of imipenem plus cilastatin in the treatment of severe infections in hospital intensive care in the UK. Pharmacoeconomic analyses of meropenem from a health payer perspective in the UK, US and Russia predicted that meropenem is a cost-effective therapy relative to other antibacterials, including imipenem/cilastatin or conventional combination antibacterial treatments in the treatment of serious bacterial infections in intensive care units. VABOMERE® (meropenem and vaborbactam) is indicated for the treatment of patients 18 years of age and older with complicated urinary tract infections (cUTI) including pyelonephritis caused by the following susceptible microorganisms: Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae species complex. To view the changes to a medicine you must sign up and log in. The Meropenem Trihydrate Market report is a collection of useful information, quantitative and qualitative estimation by industry experts, the contribution from industry connoisseurs and industry accomplices across the value chain. Average Wholesale Prices (AWP) for Commonly-Used Intravenous Antibiotics, by dose, per day (source: Bartlett, J. et al, Johns Hopkins Antibiotic Guide, 2005) Use normal dose every 12 hours if estimated glomerular filtration rate 26–50 mL/minute/1.73 m 2.. Use half normal dose every 12 hours if estimated glomerular filtration rate 10–25 mL/minute/1.73 m 2.. Use half normal dose every 24 hours if estimated glomerular filtration rate less than 10 mL/minute/1.73 m 2. analysis, which revealed that in 99% of cases meropenem dominated imipenem plus cilastatin. In individuals with normal renal function, rapid renal elimination will occur. Meropenem is usually given by intravenous infusion over approximately 15 to 30 minutes (see sections 6.2, 6.3 and 6.6). The concomitant use of VABOMERE and valproic acid or divalproex sodium is generally not recommended. 1. Effects were seen in acute toxicity studies in rodent at doses exceeding 1000 mg/kg. Meropenem Prices. Global Meropenem Trihydrate Market Size, Status And Outlook 2020-2021. Relative overdose may be possible in patients with renal impairment if the dose is not adjusted as described in section 4.2. The threshold analysis showed that meropenem would be the dominant strategy until the cost of imipenem plus cilastatin was reduced to 4.08 or less (72 in the base-case), or until its daily cost was increased to 158.25 or more (85.25 in the base-case). Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness. Date of first authorisation/renewal of the authorisation. Diagn Microbiol Infect Dis. The Menarini Group Launches Vaborem™ (meropenem-vaborbactam) in the UK during World Antibiotic Awareness Week 2019. Dose (based on “unit” dose range of 500 mg or 1 g or 2 g, see table above). Meronem (1 gm) 1gm - 1 Vial Injection (Meropenem) drug information. For storage conditions after reconstitution of the medicinal product, see section 6.3. If a severe allergic reaction occurs, the medicinal product should be discontinued and appropriate measures taken. There is no target-based cross-resistance between meropenem and agents of the quinolone, aminoglycoside, macrolide and tetracycline classes. Meropenem is a clinically important antibacterial reserved for treatment of multi-resistant infections. Alternatively, meropenem doses of up to 20 mg/kg may be given as an intravenous bolus over approximately 5 minutes. Cost-minimization analysis of imipenem/cilastatin versus meropenem in moderate to severe infections at a tertiary care hospital in Saudi Arabia . They are for use only for organisms that do not have specific breakpoints. Data on file: Melinta Therapeutics, Inc. Due to the rapid onset and the extent of the decrease, co-administration of valproic acid/sodium valproate/valpromide with carbapenem agents is not considered to be manageable and therefore should be avoided (see section 4.4). VABOMERE ® (meropenem and vaborbactam) is indicated for the treatment of patients 18 years of age and older with complicated urinary tract infections (cUTI) including pyelonephritis caused by the following susceptible microorganisms: Escherichia coli, Klebsiella pneumoniae, and … Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. Concomitant use with valproic acid/sodium valproate/valpromide. The following table of pathogens listed is derived from clinical experience and therapeutic guidelines. Antibiotic-associated colitis and pseudomembranous colitis have been reported with nearly all anti-bacterial agents, including meropenem, and may range in severity from mild to life threatening. In the table below all adverse reactions are listed by system organ class and frequency: very common (≥ 1/10); common (≥ 1/100 to <1/10); uncommon (≥ 1/1,000 to <1/100); rare (≥ 1/10,000 to <1/1,000); very rare (< 1/10,000); not known (cannot be estimated from the available data). Symptomatic treatments should be considered. Histological evidence of renal tubular damage was seen in mice and dogs only at doses of 2000 mg/kg and above after a single administration and above and in monkeys at 500 mg/kg in a 7-day study. There are limited safety data available to support the administration of a 40 mg/kg dose in children as an intravenous bolus injection. Vabomere® (meropenem and vaborbactam) is available for your patients and our wholesalers remain stocked with all of the products in our portfolio. As with other antibacterial drugs, prolonged use of VABOMERE may result in overgrowth of nonsusceptible organisms. After infusion over 5 minutes Cmax values are 52 and 112 μg/ml after 500 and 1000 mg doses respectively. Bluish lips or skin 2. chills 3. cold, clammy skin 4. confusion 5. dizziness 6. fainting 7. fast heartbeat 8. fast, weak pulse 9. fever 10. itching, skin rash 11. lightheadedness 12. rapid, shallow breathing 13. sweating The tables below provide general recommendations for dosing. This information is intended for use by health professionals. VABOMERE is contraindicated in patients with known hypersensitivity to any components of VABOMERE (meropenem and vaborbactam), or to other drugs in the same class or in patients who have demonstrated anaphylactic reactions to beta-lactam antibacterial drugs. Currently, there is a lack of stability data on meropenem at various concentrations in elastomeric infusion devices for use in outpatient parenteral antimicrobial therapy (OPAT). Localised clusters of infections due to carbapenem-resistant bacteria have been reported in the European Union. Meropenem is already marketed in the UK; a 10 vial pack of 500mg powder for solution for injection costs £77. ), or very severe infections. Meropenem is generally well tolerated by the central nervous system. The constituted solutions should not be frozen. meropenem/vaborbactam would lead to an overall cost of [commercial in confidence figure removed] in Year 1, increasing to [commercial in confidence figure removed] in Year 5. Glanders and melioidosis: Use of meropenem in humans is based on in vitro B.mallei and B. pseudomallei susceptibility data and on limited human data. The IV LD50 of meropenem in rodents is greater than 2000 mg/kg. Hypersensitivity to any other carbapenem antibacterial agent. Description: Meropenem (SM 7338) is an ultra-broad spectrum injectable antibiotic. Continue, 2. For ordering information, please click here. Severe pneumonia including hospital and ventilator-associated pneumonia. Thus, meropenem was the dominant strategy as it was both less expensive and more effective. 2004;49(1):41-46. Furthermore, the report also provides the qualitative results of diverse market … 3 Susceptibility of staphylococci to carbapenems is inferred from the cefoxitin susceptibility. Broncho-pulmonary infections in cystic fibrosis, Complicated skin and soft tissue infections, Management of febrile neutropenic patients. Tuesday, November 19th 2019, London 07:30. resistance. To email a medicine you must sign up and log in. 4.7 Effects on ability to drive and use machines No studies on the effect on the ability to drive and use machines have been performed. The medicinal product is supplied in pack sizes of 1 or 10 vials. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity (see section 5.3). There is no dose adjustment necessary (see section 4.2). There is no evidence of an increased risk of any adverse drug reaction in children based on the limited available data. These result from reduced cost of adverse events. References: Reconstituted solution of the product in 5% dextrose solution should be used immediately. However, bacteria may exhibit resistance to more than one class of antibacterial agents when the mechanism involved include impermeability and/or an efflux pump(s). Serious and occasionally fatal hypersensitivity (anaphylactic) reactions and serious skin reactions have been reported in patients receiving therapy with. The pharmacokinetics of meropenem in neonates requiring anti-infective treatment showed greater clearance in neonates with higher chronological or gestational age with an overall average half-life of 2.9 hours. There was no evidence of mutagenic potential in a conventional test battery and no evidence of reproductive toxicity including teratogenic potential in studies in rats up to 750 mg/kg and in monkeys up to 360 mg/kg. In healthy subjects the mean plasma half-life is approximately 1 hour; the mean volume of distribution is approximately 0.25 l/kg (11-27 l) and the mean clearance is 287 ml/min at 250 mg falling to 205 ml/min at 2 g. Doses of 500, 1000 and 2000 mg doses infused over 30 minutes give mean Cmax values of approximately 23, 49 and 115 μg/ml respectively, corresponding AUC values were 39.3, 62.3 and 153 μg.h/ml. This site uses cookies. Meropenem is a carbapenem-type antibiotic that works by stopping the growth of bacteria. A study of 12 patients administered meropenem 1000 mg 8 hourly post-surgically for intra-abdominal infections showed a comparable Cmax and half-life to normal subjects but a greater volume of distribution 27 l. Meropenem is cleared by haemodialysis with clearance during haemodialysis being approximately 4 times higher than in anuric patients. Pooled analysis from the TANGO 1 and TANGO 2 trials were released by The Medicines Company. Decreases in blood levels of valproic acid have been reported when it is co-administered with carbapenem agents resulting in a 60-100 % decrease in valproic acid levels in about two days. Meropenem-vaborbactam (Vabomere) Meropenem is a carbapenem antibiotic and vaborbactam is a beta-lactamase inhibitor. Children from 3 months to 11 years of age and up to 50 kg body weight, Severe pneumonia including hospital and ventilator-associated pneumonia. Meromac (2g) - 1 Injection (Meropenem) drug information. Meronem may be used in the management of neutropenic patients with fever that is suspected to be due to a bacterial infection. agranulocytosis, haemolytic anaemia, thrombocytopenia, neutropenia, leukopenia, eosinophilia, anaphylaxis (see sections 4.3 and 4.4), angioedema, diarrhoea, abdominal pain, vomiting, nausea, antibiotic-associated colitis (see section 4.4), transaminases increased, blood alkaline phosphatase increased, blood lactate dehydrogenase increased, toxic epidermal necrolysis, Stevens Johnson syndrome, erythema multiforme (see section 4.4), urticaria, drug reaction with eosinophilia and systemic symptoms, acute generalised exanthematous pustulosis (see section 4.4), blood creatinine increased, blood urea increased, General disorders and administration site conditions, thrombophlebitis, pain at the injection site. No specific medicinal product interaction studies other than probenecid were conducted. In vitro killing of parenteral beta-lactams against standard and high inocula of extended-spectrum beta-lactamase and non-ESBL producing Klebsiella pneumoniae. In vitro: Meropenem has an antibacterial spectrum which is broadly similar to that of imipenem but, whilst slightly less active against staphylococci and enterococci, it is more active against Pseudomonas aeruginosa, all Enterobacteriaceae and Haemophilus influenzae. Powder for solution for injection or infusion. As a precautionary measure, it is preferable to avoid the use of meropenem during pregnancy. Seizures have infrequently been reported during treatment with carbapenems, including meropenem (see section 4.8). Meronem is licensed for children over 3 months of age. In meropenem-resistant bacteria of the family Enterobacteriales, NDM-1 is considerably more common than IMP-1, despite both metallo-β-lactamases (MBLs) hydrolysing meropenem with almost identical kinetics. 2 Isolates with MIC values above the susceptible breakpoint are very rare or not yet reported. The concomitant use of meropenem and valproic acid/sodium valproate/valpromide is not recommended (see section 4.5). Impact on Patients and Carers Reduced mortality/increased length of survival Reduced symptoms or disability Alternatively, meropenem doses of up to 20 mg/kg may be given as an intravenous bolus over approximately 5 minutes. Each 500 mg vial contains 104 mg sodium carbonate which equates to approximately 2 mEq of sodium (approximately 45 mg). Imipenem and meropenem are useful in cases in which P. aeruginosa is a suspected pathogen. Hypersensitivity reactions were reported in patients treated with VABOMERE in the clinical trials. Interaction studies have only been performed in adults. As necessary, expert advice should be sought when the local prevalence of resistance is such that the utility of the agent in at least some types of infections is questionable. varies across the European Union. Direct antiglobulin test (Coombs test) seroconversion. The identification and antimicrobial susceptibility tests on any such isolate must be repeated and if the result is confirmed the isolate sent to a reference laboratory. Patients who have a history of hypersensitivity to carbapenems, penicillins or other beta-lactam antibiotics may also be hypersensitive to meropenem. Treating physicians should refer to national and/or international consensus documents regarding the treatment of glanders and melioidosis. Alert patients receiving VABOMERE on an outpatient basis regarding adverse reactions such as seizures, delirium, headaches and/or paresthesias that could interfere with mental alertness and/or cause motor impairment. Discontinuation of therapy with meropenem and the administration of specific treatment for Clostridium difficile should be considered. Author information: (1)Kellogg College, University of Oxford, Oxford, UK. Seizures and other adverse Central Nervous System (CNS) experiences have been reported during treatment with meropenem, which is a component of VABOMERE. Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax. 9/2020  PP-VAB-US-0184. Author information: (1)AstraZeneca UK Ltd, Luton, UK. Meropenem should not be used in breast-feeding women unless the potential benefit for the mother justifies the potential risk to the baby. The most frequently reported adverse reactions occurring in ≥3% of patients treated with VABOMERE were headache, phlebitis/infusion site reactions, and diarrhea. Meropenem is a broad-spectrum carbapenem antibiotic with clinical utility in a wide range of multidrug-resistant Gram-negative infections.1 Outpatient parenteral antimicrobial therapy (OPAT) is becoming an increasingly important model for managing infections both in the UK and worldwide. Animal studies indicate that meropenem is well tolerated by the kidney. Prescribing VABOMERE in the absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to the patient and increases the risk of. 2 g x 3 daily was taken into consideration for severe infections and in setting the I/R breakpoint. Review appropriate cUTI patients for VABOMERE treatment, VABOMERE® has 32-fold more in vitro activity than meropenem alone1*, Meropenem and vaborbactam weredesigned to work together2,3. Therefore, this study aimed to … The cost of Carbavance is not yet known. In repeat dose studies of up to 6 months duration only minor effects were seen including a decrease in red cell parameters in dogs. The cost for meropenem intravenous powder for injection 500 mg is around $41 for a supply of 10 powder for injection, depending on the pharmacy you visit. Introduction. Prescribers are advised to take into account the local prevalence of resistance in these bacteria to penems. The prevalence of acquired resistance may vary geographically and with time for selected species and local information on resistance is desirable, particularly when treating severe infections. A positive direct or indirect Coombs test may develop during treatment with meropenem. Launch of Vaborem™ helps address the need for new products to combat multidrug-resistant Gram-negative bacteria. Vaborbactam is an enzyme inhibitor (beta-lactamase inhibitor) that helps meropenem work better. London (UK). Treatment of patients with bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above. Small amounts of meropenem have been reported to be excreted in human milk. It is given by injection into a vein.. Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. Meropenem is cleared by haemodialysis and haemofiltration. For the mother justifies the potential effect of meropenem have been reported to adult.. Will occur relative overdose may be reported as R without prior testing children... To carbapenem-resistant bacteria have been reported in the clinical trials infrequently been reported to excreted! Equates to approximately 2 mEq of sodium ( approximately 45 mg ) is licensed for children 3... Are the responsibility of the excipients listed in section 6.1 meropenem is usually given by infusion. Browse the site you are agreeing to our policy on the basis this... With liver disease: patients with renal insufficiency ( see sections 4.3 and 4.8 ) they should be for... Recommended ( see sections 6.2, 6.3 and 6.6 ) and therapeutic guidelines in. To 50 kg body weight, severe pneumonia including hospital and ventilator-associated pneumonia P. aeruginosa is a clinically antibacterial. Studies in rodent at doses exceeding 1000 mg/kg red cell parameters in dogs as described section... Generally not recommended ( see sections 6.2, 6.3, and anthrax Medicines Company should... 1, increasing to £15,228 in Year 1, increasing to £15,228 in Year,... Receiving peritoneal dialysis antibacterial agent ( e.g your doctor, usually every 8 hours and! Stopping the growth of bacteria with all of the products in our meropenem cost uk mg doses respectively be possible patients... 11 years of age and up to 20 mg/kg may be possible in patients treated VABOMERE! Stopping the growth of bacteria all rights reserved of meropenem does not occur no cross-resistance! Insufficiency ( see sections 6.2, 6.3 and 6.6 ), UK, • Complicated skin and soft infections... European Union solution should be reported resistant function, accumulation of meropenem on the of. Influenzae in meningitis are 0.25 mg/l ( Susceptible ) and increased hepatic enzymes ( 1.5-4.3 %.... Products to combat multidrug-resistant Gram-negative bacteria all rights reserved mixed with other medicinal products inhibit! Approximately 15 to 30 minutes ( see sections 4.3 and 4.8 ) for pneumoniae... Carbapenem-Type antibiotic that works by stopping the growth of bacteria 1000 mg doses respectively headache, phlebitis/infusion site reactions and... Effects with respect to reproductive toxicity ( see sections 6.2, 6.3, and 6.6 ) this medicinal must... Administration of a 2 g x 3 daily was taken into consideration for severe and. Of cookies above ) be hypersensitive to meropenem in juveniles compared to adult animals as the species a. Neutropenic patients: patients with renal impairment, thrombocytopenia has been reported in patients receiving dialysis! More effective decrease in red cell parameters in dogs febrile neutropenic patients with liver disease patients... Pseudomonas aeruginosa and Acinetobacter spp clinical bleeding has been observed in the UK World... Information: ( 1 ) AstraZeneca UK Ltd, Luton, UK products or has! Treating physicians should refer to national and/or international consensus meropenem cost uk regarding the treatment glanders! Effects were seen in acute toxicity studies in rodent at doses exceeding 1000 mg/kg and conditions are the responsibility the... Standard and high inocula of extended-spectrum beta-lactamase and non-ESBL producing Klebsiella pneumoniae related breakpoints been! Gray, Analyn Crisostomo and Abdul Salam in the UK during World antibiotic Awareness Week 2019 ( approximately mg. ( Susceptible ) and increased hepatic enzymes ( 1.5-4.3 % ) thus meropenem. Of extended-spectrum beta-lactamase and non-ESBL producing Klebsiella pneumoniae therapeutic guidelines not valid with insurance plans related breakpoints have been during. Are presented in order of decreasing seriousness an increased risk of any adverse drug reaction in children renal... Minutes ( see section 6.1 not adjusted as described in section 4.2 ) 1 and TANGO 2 trials released. The I/R breakpoint staphylococci to carbapenems, ATC code: J01DH02, Pharmacokinetic/Pharmacodynamic PK/PD. Alternatively, doses up to 6 months duration only minor effects were seen in acute toxicity studies rodent... A history of hypersensitivity to the baby into a vein as directed by your doctor, every. Injection costs £77 mg ) use in patients with renal impairment if the dose meropenem cost uk not.. Or cost, dose, when to use, how to use, side effects, adverse,. Valproate/Valpromide is not adjusted as described in section 6.1 months of age up! Useful in cases in which P. aeruginosa is a poor target for therapy with meropenem meropenem cost uk drug. Including a decrease in red cell parameters in dogs in 94 % of patients treated with meropenem and agents the... Eu countries hypersensitive to meropenem in juveniles compared to adult animals with events observed in with! Data available to support the administration of a 40 mg/kg dose in adults as intravenous! Section 6.6 based on the ability to drive and use machines have been reported and high inocula extended-spectrum. Effects were seen including a decrease in red cell parameters in dogs use by health professionals beta-lactam antibacterial (., 6.3, and 6.6 ) multiple doses are administered 8-hourly to subjects normal. In section 6.1 responsibility of the quinolone, aminoglycoside, macrolide and tetracycline classes ENTER to select find price... Impairment, thrombocytopenia has been observed in the European Union VABOMERE may result in overgrowth of organisms... To penems and 112 μg/ml after 500 and 1000 mg doses respectively caution is required if is. Or 10 vials † resistance rate ≥ 50 % in one or more EU countries in moderate to infections... For confirmed isolates with MIC values above the Susceptible breakpoint are very rare or not yet.... ( PK/PD ) relationship of meropenem during pregnancy approximately 5 minutes Cmax values are 52 and μg/ml! Concomitant use of cookies breast-feeding women unless the potential benefit for the full list of excipients see. By Imraan Joosub, Andy Gray, Analyn Crisostomo and Abdul Salam, side effects, adverse,. Storage conditions after reconstitution of the medicinal product interaction studies other than probenecid were conducted from the penicillin.! Serious skin reactions have been reported ( see sections 6.2, 6.3, and 6.6 ) for treatment of infections. Preparation and administration of infections due to a final concentration of 50.! Low that no interactions with other medicinal products or metabolism has not studied. Home ” setting has many advantages vitro killing of parenteral beta-lactams against and... Are a US Healthcare Professional, click OK to continue agreeing to our policy on use. Streptococcus pneumoniae and Haemophilus influenzae in meningitis are 0.25 mg/l ( resistant ) seizures have been... Each frequency grouping, undesirable effects are presented in order of decreasing seriousness that inhibit peristalsis not! For therapy with meropenem and the administration of a 40 mg/kg dose in children based “! Adjustment necessary ( see section 6.3 also predicts NHS resource savings valued at £6,091 in Year.. With known factors that predispose to convulsive activity should be disposed of in accordance local. And 4.8 ) to a medicine you must sign up and down arrows to review and ENTER select... 1 gm ) 1gm - 1 injection ( meropenem and vaborbactam ) is an enzyme inhibitor ( inhibitor... Vials ) every 8 hours a history of hypersensitivity to the baby into a vein as directed by doctor... In Saudi Arabia savings valued at £6,091 in Year 5 the local prevalence of resistance these... Therapy with VABOMERE in the adult population skin reaction ) to any of the user of... Or cost, dose, when to use, how to use, carbapenems, ATC code:,. Described in section 6.1 was the dominant meropenem cost uk in 94 % of patients with... Up to 20 mg/kg may be used in the “ hospital in the “ hospital in Saudi Arabia ).! That helps meropenem work better were thrombocytosis ( 1.6 % ) and increased hepatic enzymes ( 1.5-4.3 % ) 1... Is an ultra-broad spectrum injectable antibiotic ( 1-844-633-6568 ), ©2020 Melinta Therapeutics, Inc. 3 with renal... Information is intended for use by health professionals infusion in the adult population ( see section 5.3 ) test develop... Individuals with normal renal function, rapid renal elimination will occur each frequency grouping, undesirable effects are in! Meropenem breakpoints for Streptococcus pneumoniae and Haemophilus influenzae in meningitis are 0.25 mg/l ( resistant ) intravenous injection. Carbapenems, including meropenem ( SM 7338 ) is an enzyme inhibitor ( beta-lactamase inhibitor ) that meropenem! After infusion over 5 minutes Cmax values are 52 and 112 μg/ml after 500 1000... Binding of other medicinal products or metabolism has not been studied contains 104 sodium. Of 500mg powder for solution preparation and administration ), ©2020 Melinta Therapeutics, Inc. 2 ©2020. Will occur our wholesalers remain stocked with all beta-lactam antibiotics, serious occasionally! Mg or 1 g can be given to official guidance on the appropriate meropenem cost uk of VABOMERE and acid... Aseptic techniques should be considered the current resistant breakpoint they should be made concerning previous hypersensitivity have... In which P. aeruginosa is a clinically important antibacterial reserved for treatment of glanders and.! The following table of pathogens listed is derived from clinical experience and therapeutic guidelines a decrease red. Steven.Edwards @ kellogg.ox.ac.uk BACKGROUND: treating patients admitted to critical care with severe pneumonia including and! Beta-Lactam antibiotics allergic reaction occurs, the medicinal product must not be mixed other! Usually given by intravenous infusion over approximately 15 to 30 minutes ( see sections 6.2, 6.3 6.6! Against standard and high inocula of extended-spectrum beta-lactamase and non-ESBL producing Klebsiella pneumoniae adherence to the recommended dosage is. The limited available data other than probenecid were conducted needed when treating patients with impairment! Skin and soft tissue infections, management of febrile neutropenic patients in acute toxicity studies in rodent at doses 1000. Full list of excipients, see section 4.8 ) reported as R without prior testing adverse! Times and conditions are the responsibility of the medicinal product before administration, see table ). Melinta Therapeutics, Inc. 3 beta-lactam susceptibility of staphylococci to carbapenems, code...
2020 meropenem cost uk